Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VHL | P40337 | 15/20 | 0.65 |
| ▸ | ELOC | Q15369 | 8/20 | 0.49 |
| ▸ | ELOB | Q15370 | 8/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.34 |
| ▸ | CDK2 | P24941 | 2/20 | 0.34 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16276321 | 0.89 | VHL (0.51) | VHLELOCELOBCCNE1CDK2 | |
| SCHEMBL16276344 | 0.87 | VHL (0.48) | VHLELOCELOBCCNE1CDK2 | |
| SCHEMBL20975657 | 0.87 | VHL (0.48) | VHLELOCELOBCCNE1CDK2 | |
| SCHEMBL15126148 | 0.82 | VHL (0.63) | VHLELOCELOBP2RX7TSHR | |
| SCHEMBL15110182 | 0.82 | VHL (0.77) | VHLELOCELOBCCNE1CDK2 | |
| SCHEMBL15110241 | 0.82 | VHL (0.77) | VHLELOCELOBCCNE1CDK2 | |
| SCHEMBL21697226 | 0.81 | VHL (0.61) | VHLELOCELOBTSHR | |
| SCHEMBL15126111 | 0.81 | VHL (0.61) | VHLELOCELOBTSHR | |
| SCHEMBL15125912 | 0.81 | VHL (0.76) | VHLELOCELOBCCNE1CDK2 | |
| SCHEMBL16277194 | 0.81 | VHL (0.76) | VHLELOCELOBCCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10730862-B2 | Compounds and methods for the enhanced degradation of targeted proteins and other polypeptides by an E3 ubiquitin ligase | YALE UNIVERSITY (US) | 2020-08-04 | — | — | US | disclosed |
| US-20190127359-A1 | Compounds & Methods for the Enhanced Degradation of Targeted Proteins & Other Polypeptides by an E3 Ubiquitin Ligase | UNIV YALE (US) | 2019-05-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10730862-B2 | Compounds and methods for the enhanced degradation of targeted proteins and other polypeptides by an E3 ubiquitin ligase | VHL, MDM2, NEDD4 | VHL 1/4885ELOC 185/4885ELOB 209/4885 |
| US-20190127359-A1 | Compounds & Methods for the Enhanced Degradation of Targeted Proteins & Other Polypeptides by an E3 Ubiquitin Ligase | MDM2, VHL, XIAP | VHL 2/4885ELOC 211/4885ELOB 249/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.