Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7602380 | 0.78 | ALDH1A1 (0.74) | ALDH1A1HPGDMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL20976503 | 0.77 | MEN1 (0.52) | ALDH1A1MEN1KMT2APOLBSMN1; SMN2 | |
| SCHEMBL20976557 | 0.75 | ALDH1A1 (0.41) | ALDH1A1MEN1KMT2APOLBSMN1; SMN2 | |
| SCHEMBL4323101 | 0.73 | ALDH1A1 (0.75) | ALDH1A1HPGDMEN1KMT2APOLB | |
| SCHEMBL24288982 | 0.73 | ALDH1A1 (0.73) | ALDH1A1HPGDMEN1KMT2APOLB | |
| SCHEMBL13601160 | 0.73 | ALDH1A1 (0.79) | ALDH1A1HPGDMEN1KMT2APOLB | |
| SCHEMBL20976529 | 0.71 | TSHR (0.64) | ALDH1A1HPGDMEN1KMT2APOLB | |
| SCHEMBL20976534 | 0.71 | TSHR (0.54) | ALDH1A1MEN1KMT2APOLBHSD17B10 | |
| SCHEMBL20976512 | 0.71 | MEN1 (0.58) | ALDH1A1MEN1KMT2APOLBSMN1; SMN2 | |
| SCHEMBL11637 | 0.70 | SMN1; SMN2 (0.65) | ALDH1A1KMT2ASMN1; SMN2HSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406389-B1 | METHODS AND COMPOSITIONS FOR CELL-PROLIFERATION-RELATED DISORDERS | AGIOS PHARMACEUTICALS INC (US) | 2019-05-08 | — | — | EP | disclosed |