Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 19/20 | 0.80 |
| ▸ | CCR5 | P51681 | 3/20 | 0.80 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.53 |
| ▸ | CCR1 | P32246 | 1/20 | 0.44 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15081517 | 1.00 | CCR2 (0.80) | CCR2CCR5KCNH2CCR1TMEM97 | |
| SCHEMBL15081515 | 1.00 | CCR2 (0.80) | CCR2CCR5KCNH2CCR1TMEM97 | |
| SCHEMBL14945898 | 0.98 | CCR2 (0.81) | CCR2CCR5KCNH2CCR1TMEM97 | |
| SCHEMBL14945902 | 0.98 | CCR2 (0.81) | CCR2CCR5KCNH2CCR1TMEM97 | |
| SCHEMBL15081508 | 0.97 | CCR2 (0.84) | CCR2CCR5KCNH2CCR1TMEM97 | |
| SCHEMBL20976586 | 0.97 | CCR2 (0.84) | CCR2CCR5KCNH2CCR1TMEM97 | |
| SCHEMBL15081475 | 0.97 | CCR2 (0.84) | CCR2CCR5KCNH2CCR1TMEM97 | |
| SCHEMBL20976601 | 0.95 | CCR2 (0.73) | CCR2CCR5KCNH2CCR1TMEM97 | |
| SCHEMBL20976575 | 0.91 | CCR2 (0.95) | CCR2CCR5KCNH2CCR1TMEM97 | |
| SCHEMBL15081425 | 0.91 | CCR2 (0.66) | CCR2CCR5KCNH2TMEM97SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2731941-B1 | NOVEL AND SELECTIVE CCR2 ANTAGONISTS | BOEHRINGER INGELHEIM INT (DE) | 2019-05-08 | — | — | EP | disclosed |