Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA7 | P43166 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4849364 | 0.74 | CA12 (0.63) | MAPTTDP1KMT2AMEN1CA12 | |
| SCHEMBL1321669 | 0.72 | MAPT (0.51) | MAPTTDP1KMT2AMEN1CA12 | |
| SCHEMBL582414 | 0.70 | MAPT (0.68) | MAPTTDP1KMT2AMEN1CA12 | |
| SCHEMBL14612801 | 0.70 | TDP1 (0.53) | MAPTTDP1KMT2AMEN1CA12 | |
| SCHEMBL29952661 | 0.69 | KMT2A (0.52) | MAPTTDP1KMT2AMEN1CA12 | |
| SCHEMBL2799192 | 0.69 | KMT2A (0.52) | MAPTTDP1KMT2AMEN1CA12 | |
| SCHEMBL21863298 | 0.69 | HTT (0.45) | TDP1KMT2AMEN1CA12CA1 | |
| SCHEMBL241586 | 0.68 | MAPT (0.51) | MAPTTDP1KMT2AMEN1CA12 | |
| SCHEMBL421547 | 0.68 | MAPT (0.51) | MAPTTDP1KMT2AMEN1CA12 | |
| SCHEMBL4501917 | 0.68 | HTT (0.51) | MAPTTDP1KMT2AMEN1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3093291-B1 | DISUBSTITUTED OCTAHY - DROPYRROLO [3,4-C]PYRROLES AS OREXIN RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2019-05-08 | — | — | EP | disclosed |