Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 13/20 | 0.70 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.53 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.53 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.53 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.53 |
| ▸ | KDM5A | P29375 | 3/20 | 0.44 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.44 |
| ▸ | KDM4A | O75164 | 1/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.42 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.42 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.39 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20979030 | 0.91 | KDM4C (0.70) | KDM4CMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL20979032 | 0.85 | KDM4C (0.57) | KDM4CMAPK14KDM5AKDM5BKDM4A | |
| SCHEMBL16034499 | 0.82 | KDM4C (1.00) | KDM4CMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL20978965 | 0.80 | KDM4C (0.72) | KDM4CMAPK14KDM5AKDM5BKDM4A | |
| SCHEMBL20979070 | 0.80 | KDM4C (0.72) | KDM4CMAPK14KDM5AKDM5BKDM4A | |
| SCHEMBL20978851 | 0.76 | KDM4C (0.73) | KDM4CKDM5AKDM5BKDM4AKDM2B | |
| SCHEMBL16033165 | 0.75 | KDM4C (0.67) | KDM4CMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL16032983 | 0.74 | KDM4C (1.00) | KDM4CMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL30023277 | 0.73 | MAPK14 (0.87) | KDM4CMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL20978917 | 0.73 | KDM4C (0.67) | KDM4CMAPK14KDM5AKDM2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2969007-B1 | HISTONE DEMETHYLASE INHIBITORS | CELGENE QUANTICEL RES INC (US) | 2019-05-08 | — | — | EP | disclosed |