Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PFKFB3 | Q16875 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 8/20 | 0.43 |
| ▸ | RAB9A | P51151 | 8/20 | 0.43 |
| ▸ | MEN1 | O00255 | 7/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | UBE2N | P61088 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20979169 | 0.94 | PFKFB3 (0.46) | PFKFB3NPC1RAB9AMEN1KMT2A | |
| SCHEMBL21129229 | 0.93 | PFKFB3 (0.42) | PFKFB3NPC1RAB9AMEN1KMT2A | |
| SCHEMBL20979107 | 0.93 | MEN1 (0.51) | PFKFB3NPC1RAB9AMEN1KMT2A | |
| SCHEMBL21129546 | 0.93 | GFER (0.49) | PFKFB3NPC1RAB9AMEN1KMT2A | |
| SCHEMBL21129224 | 0.93 | PFKFB3 (0.42) | PFKFB3NPC1RAB9AMEN1KMT2A | |
| SCHEMBL29526976 | 0.93 | PFKFB3 (0.42) | PFKFB3NPC1RAB9AMEN1KMT2A | |
| SCHEMBL20978992 | 0.92 | NPC1 (0.50) | PFKFB3NPC1RAB9AMEN1KMT2A | |
| SCHEMBL21129493 | 0.92 | PFKFB3 (0.45) | PFKFB3NPC1RAB9AMEN1KMT2A | |
| SCHEMBL21129782 | 0.92 | MEN1 (0.50) | PFKFB3NPC1RAB9AMEN1KMT2A | |
| SCHEMBL21129792 | 0.92 | PFKFB3 (0.45) | PFKFB3NPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10954232-B2 | Pyrazole derivative as ALK5 inhibitor and uses thereof | HANMI PHARMACEUTICAL CO., LTD. (KR) | 2021-03-23 | — | — | US | disclosed |
| US-20190194198-A1 | NOVEL PYRAZOLE DERIVATIVE AS ALK5 INHIBITOR AND USES THEREOF | HANMI PHARMACEUTICAL CO., LTD. (KR) | 2019-06-27 | — | — | US | disclosed |
| EP-3480193-A1 | NOVEL PYRAZOLE DERIVATIVE AS ALK5 INHIBITOR AND USES THEREOF | Hanmi Pharmaceutical Co., Ltd. (KR) | 2019-05-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190194198-A1 | NOVEL PYRAZOLE DERIVATIVE AS ALK5 INHIBITOR AND USES THEREOF | ALK, SMAD3, TGFBR1 | PFKFB3 1433/4885NPC1 4232/4885RAB9A 2714/4885 |
| US-10954232-B2 | Pyrazole derivative as ALK5 inhibitor and uses thereof | ALK, SMAD3, TGFBR1 | PFKFB3 1769/4885NPC1 3974/4885RAB9A 2687/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.