Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.31 |
| ▸ | ASPH | Q12797 | 1/20 | 0.31 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.31 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12166670 | 0.80 | LMNA (0.48) | EPHX1ALDH1A1LMNA | |
| SCHEMBL12820520 | 0.77 | EPHX1 (0.61) | EPHX1EGLN1ALDH1A1PDE4APDE4B | |
| SCHEMBL12166450 | 0.75 | MAPT (0.45) | CYP19A1EPHX1EGLN1GAAMAPT | |
| SCHEMBL2866869 | 0.75 | EPHX1 (0.65) | EPHX1EGLN1ALDH1A1PDE4APDE4B | |
| SCHEMBL13195790 | 0.74 | CYP19A1 (0.46) | CYP19A1EPHX1TRPM8LMNA | |
| SCHEMBL12167270 | 0.73 | EPHX1 (0.67) | CYP19A1EPHX1GAAALDH1A1 | |
| SCHEMBL18203087 | 0.73 | EPHX1 (0.67) | CYP19A1EPHX1GAAALDH1A1 | |
| SCHEMBL2860088 | 0.72 | EPHX1 (0.43) | EPHX1EGLN1GAAALDH1A1 | |
| SCHEMBL25785978 | 0.72 | EPHX1 (0.42) | CYP19A1EPHX1TRPM8 | |
| SCHEMBL18265727 | 0.72 | EPHX1 (0.70) | CYP19A1EPHX1TRPM8GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970335-B1 | MACROCYCLIC AND BICYCLIC INHIBITORS OF HEPATITIS C VIRUS | GILEAD SCIENCES INC (US) | 2019-05-08 | — | — | EP | disclosed |