Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 7/20 | 0.41 |
| ▸ | KLK1 | P06870 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
| ▸ | PRCP | P42785 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | F9 | P00740 | 2/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20979584 | 0.90 | F11 (0.49) | F11KLK1HTTMEN1MAPT | |
| SCHEMBL20979725 | 0.90 | F11 (0.49) | F11KLK1HTTMEN1MAPT | |
| SCHEMBL17481099 | 0.90 | F11 (0.48) | F11KLK1HTTMEN1MAPT | |
| SCHEMBL20979724 | 0.90 | F11 (0.39) | F11KLK1HTTMEN1MAPT | |
| SCHEMBL20979507 | 0.89 | F11 (0.35) | F11KLK1PRCPPTPN1F9 | |
| SCHEMBL20979650 | 0.88 | F11 (0.43) | F11KLK1HTTMEN1MAPT | |
| SCHEMBL19278462 | 0.81 | F11 (0.38) | F11KLK1PRCPLMNAPTPN1 | |
| SCHEMBL19278152 | 0.81 | F11 (0.38) | F11KLK1PRCPLMNAPTPN1 | |
| SCHEMBL17477793 | 0.81 | F11 (0.58) | F11KLK1HTTMEN1MAPT | |
| SCHEMBL17477807 | 0.81 | F11 (0.58) | F11KLK1HTTMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3180327-B1 | FACTOR XIa INHIBITORS | MERCK SHARP & DOHME (US) | 2019-05-08 | — | — | EP | disclosed |