Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.48 |
| ▸ | CHRM4 known ✓ | P08173 | 1/20 | 0.48 |
| ▸ | CHRM5 known ✓ | P08912 | 1/20 | 0.48 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.48 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.48 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | ATG4B | Q9Y4P1 | 2/20 | 0.59 |
| ▸ | APAF1 | O14727 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL15798292 | 1.00 | HSP90AA1 (0.60) | HSP90AA1KMT2ASMN1; SMN2MEN1PLA2G1B | |
| Bromide SCHEMBL20981582 | 1.00 | HSP90AA1 (0.60) | HSP90AA1KMT2ASMN1; SMN2MEN1PLA2G1B | |
| Bromide SCHEMBL16445149 | 1.00 | HSP90AA1 (0.60) | HSP90AA1KMT2ASMN1; SMN2MEN1PLA2G1B | |
| Bromide SCHEMBL19461812 | 1.00 | HSP90AA1 (0.60) | HSP90AA1KMT2ASMN1; SMN2MEN1PLA2G1B | |
| SCHEMBL5289867 | 0.98 | MEN1 (0.58) | HSP90AA1KMT2ASMN1; SMN2MEN1PLA2G1B | |
| SCHEMBL5294758 | 0.98 | MEN1 (0.58) | HSP90AA1KMT2ASMN1; SMN2MEN1PLA2G1B | |
| SCHEMBL413479 | 0.98 | MEN1 (0.58) | HSP90AA1KMT2ASMN1; SMN2MEN1PLA2G1B | |
| SCHEMBL5298378 | 0.98 | MEN1 (0.58) | HSP90AA1KMT2ASMN1; SMN2MEN1PLA2G1B | |
| SCHEMBL412476 | 0.98 | MEN1 (0.58) | HSP90AA1KMT2ASMN1; SMN2MEN1PLA2G1B | |
| SCHEMBL413208 | 0.98 | MEN1 (0.58) | HSP90AA1KMT2ASMN1; SMN2MEN1PLA2G1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190291046-A1 | OXYGEN SEPARATION MEMBRANE | SHARP KABUSHIKI KAISHA (JP) | 2019-09-26 | — | — | US | disclosed |
| EP-3485965-A1 | OXYGEN SEPARATION MEMBRANE | Sharp Kabushiki Kaisha (JP) | 2019-05-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190291046-A1 | OXYGEN SEPARATION MEMBRANE | NCLN, OXA1L, MB | CHRM2 2009/4885CHRM4 2126/4885CHRM5 1574/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.