Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 11/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.72 |
| ▸ | MEN1 | O00255 | 8/20 | 0.72 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.72 |
| ▸ | MAPT | P10636 | 8/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.65 |
| ▸ | LMNA | P02545 | 5/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.65 |
| ▸ | HTT | P42858 | 3/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.65 |
| ▸ | TP53 | P04637 | 1/20 | 0.65 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.65 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.64 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 8/20 | 0.58 |
| ▸ | NPC1 | O15118 | 8/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | GFER | P55789 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18591317 | 1.00 | GAA (0.76) | GAAKMT2AMEN1HSP90AA1MAPT | |
| SCHEMBL19425616 | 0.85 | NCOA1 (0.69) | GAAKMT2AMEN1HSP90AA1MAPT | |
| SCHEMBL12807528 | 0.84 | MEN1 (0.72) | GAAKMT2AMEN1HSP90AA1MAPT | |
| SCHEMBL20982002 | 0.84 | KMT2A (1.00) | GAAKMT2AMEN1HSP90AA1MAPT | |
| SCHEMBL15742301 | 0.84 | KMT2A (1.00) | GAAKMT2AMEN1HSP90AA1MAPT | |
| SCHEMBL16316772 | 0.83 | GAA (0.52) | GAAKMT2AMEN1HSP90AA1MAPT | |
| SCHEMBL1108655 | 0.83 | GAA (0.52) | GAAKMT2AMEN1HSP90AA1MAPT | |
| SCHEMBL12218014 | 0.83 | NCOA1 (0.74) | GAAKMT2AMEN1HSP90AA1MAPT | |
| SCHEMBL6712644 | 0.83 | NCOA1 (0.74) | GAAKMT2AMEN1HSP90AA1MAPT | |
| SCHEMBL12807532 | 0.82 | KMT2A (0.69) | GAAKMT2AMEN1HSP90AA1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2922541-B1 | PYRIDYL HYDRAZONES FOR THE TREATMENT OF TUBERCULOSIS AND RELATED DISEASES | TECNIMEDE SOCIEDADE TECNICO MEDICINAL S (PT) | 2019-05-22 | — | — | EP | claimed |