Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GZMB | P10144 | 2/20 | 0.38 |
| ▸ | CMA1 | P23946 | 1/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | REN | P00797 | 14/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20701984 | 0.90 | GZMB (0.39) | GZMBCMA1ITGB3ITGA2BKMT2A | |
| SCHEMBL20701989 | 0.90 | GZMB (0.39) | GZMBCMA1ITGB3ITGA2BKMT2A | |
| SCHEMBL20701987 | 0.90 | GZMB (0.39) | GZMBCMA1ITGB3ITGA2BKMT2A | |
| SCHEMBL20701589 | 0.90 | GZMB (0.38) | GZMBCMA1ITGB3ITGA2BKMT2A | |
| SCHEMBL20701584 | 0.90 | GZMB (0.38) | GZMBCMA1ITGB3ITGA2BKMT2A | |
| SCHEMBL20701586 | 0.90 | GZMB (0.38) | GZMBCMA1ITGB3ITGA2BKMT2A | |
| SCHEMBL20701811 | 0.87 | ACE (0.41) | CMA1ITGB3ITGA2BKMT2AREN | |
| SCHEMBL20701812 | 0.87 | ACE (0.41) | CMA1ITGB3ITGA2BKMT2AREN | |
| SCHEMBL20701808 | 0.87 | ACE (0.41) | CMA1ITGB3ITGA2BKMT2AREN | |
| SCHEMBL19182515 | 0.84 | GZMB (0.40) | GZMBCMA1KMT2AREN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190151484-A2 | CYCLIC UREA COMPOUNDS AS GRANZYME B INHIBITORS | VIDA THERAPEUTICS INC. (CA) | 2019-05-23 | — | — | US | disclosed |