Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A1 | P22736 | 8/20 | 0.81 |
| ▸ | TERT | O14746 | 5/20 | 0.81 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.75 |
| ▸ | CASP1 | P29466 | 1/20 | 0.75 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.75 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.75 |
| ▸ | TP53 | P04637 | 1/20 | 0.75 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.75 |
| ▸ | MAPT | P10636 | 1/20 | 0.75 |
| ▸ | HPGD | P15428 | 1/20 | 0.75 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.75 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.75 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.75 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.75 |
| ▸ | HSP90AB1 | P08238 | 5/20 | 0.74 |
| ▸ | CASP3 | P42574 | 5/20 | 0.74 |
| ▸ | CDC37 | Q16543 | 5/20 | 0.74 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.72 |
| ▸ | CCR6 | P51684 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20988609 | 0.91 | NR4A1 (0.81) | NR4A1TERTPTPN1CASP1ABHD6 | |
| SCHEMBL12395123 | 0.89 | NR4A1 (1.00) | NR4A1TERTPTPN1CASP1ABHD6 | |
| SCHEMBL21527566 | 0.89 | NR4A1 (0.79) | NR4A1TERTPTPN1CASP1ABHD6 | |
| Pristimerin SCHEMBL17328930 | 0.86 | NR4A1 (1.00) | NR4A1TERTPTPN1CASP1ABHD6 | |
| Pristimerin SCHEMBL31238187 | 0.86 | NR4A1 (1.00) | NR4A1TERTPTPN1CASP1ABHD6 | |
| Pristimerin SCHEMBL30271494 | 0.86 | NR4A1 (1.00) | NR4A1TERTPTPN1CASP1ABHD6 | |
| Pristimerin SCHEMBL15020 | 0.86 | NR4A1 (1.00) | NR4A1TERTPTPN1CASP1ABHD6 | |
| SCHEMBL20988491 | 0.86 | NR4A1 (0.89) | NR4A1TERTPTPN1CASP1ABHD6 | |
| SCHEMBL18782084 | 0.85 | NR4A1 (0.84) | NR4A1TERTPTPN1CASP1ABHD6 | |
| Celastrol SCHEMBL17430781 | 0.84 | HSP90AA1 (1.00) | NR4A1TERTPTPN1CASP1ABHD6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10808005-B2 | Ligand for orphan nuclear receptor Nur77 and uses thereof | IXMEDICINE (XIAMEN) BIOLOGICAL TECHNOLOGY COMPANY LIMITED (CN) | 2020-10-20 | — | — | US | disclosed |
| US-20190330261-A1 | LIGAND FOR ORPHAN NUCLEAR RECEPTOR NUR77 AND USES THEREOF | XIAMEN UNIVERSITY (CN) | 2019-10-31 | — | — | US | disclosed |
| EP-3480207-A1 | ORPHAN NUCLEAR RECEPTOR NUR77 LIGAND AND APPLICATION THEREOF | Xiamen University (CN) | 2019-05-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10808005-B2 | Ligand for orphan nuclear receptor Nur77 and uses thereof | NR2E3, NR0B1, NR0B2 | NR4A1 15/4885TERT 2540/4885PTPN1 2999/4885 |
| US-20190330261-A1 | LIGAND FOR ORPHAN NUCLEAR RECEPTOR NUR77 AND USES THEREOF | NR2E3, NR0B1, NR0B2 | NR4A1 15/4885TERT 2540/4885PTPN1 2999/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.