SCHEMBL20988827

SCHEMBL20988827

COc1cc2c(cc1C)-c1c(c(C(=O)N(C)C(C)(C)C)nn1-c1ccsc1)CO2

nearest known ligand 0.32

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ PDE7A Q13946 1/20 0.32
▸ PDE3A Q14432 1/20 0.32
▸ PDE10A Q9Y233 1/20 0.32
▸ NR1H4 Q96RI1 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22626279 0.92 CCNA2 (0.30) —
SCHEMBL17382008 0.92 PDE7A (0.32) PDE7APDE3APDE10ANR1H4
SCHEMBL16334006 0.92 PDE7A (0.32) PDE7APDE3APDE10ANR1H4
SCHEMBL29539301 0.92 PDE7A (0.32) PDE7APDE3APDE10ANR1H4
SCHEMBL29538471 0.92 PDE7A (0.32) PDE7APDE3APDE10ANR1H4
SCHEMBL16377965 0.90 — —
SCHEMBL16377848 0.90 CCNA2 (0.32) PDE7APDE3APDE10A
SCHEMBL29538892 0.90 PDE7A (0.31) PDE7APDE3APDE10A
SCHEMBL16377735 0.90 PDE7A (0.31) PDE7APDE3APDE10A
SCHEMBL16377980 0.89 PDE7A (0.34) PDE7APDE3APDE10A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10941152-B2 Pyrazole compounds as modulators of FSHR and uses thereof ARES TRADING S.A. (CH) 2021-03-09 — — US disclosed
US-20190135823-A1 PYRAZOLE COMPOUNDS AS MODULATORS OF FSHR AND USES THEREOF TOCOPHERX, INC. 2019-05-09 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190135823-A1 PYRAZOLE COMPOUNDS AS MODULATORS OF FSHR AND USES THEREOF FSHR, GNRHR, LHCGR PDE7A 195/4885PDE3A 379/4885PDE10A 464/4885
US-10941152-B2 Pyrazole compounds as modulators of FSHR and uses thereof FSHR, GNRHR, LHCGR PDE7A 195/4885PDE3A 379/4885PDE10A 464/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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