Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | B3GNT2 | Q9NY97 | 1/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 11/20 | 0.40 |
| ▸ | S1PR4 | O95977 | 7/20 | 0.40 |
| ▸ | S1PR2 | O95136 | 4/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 8/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | FDPS | P14324 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18425730 | 0.85 | ALDH1A1 (0.41) | KDM4EALDH1A1S1PR3S1PR4S1PR2 | |
| SCHEMBL1284717 | 0.80 | ALDH1A1 (0.34) | KDM4EALDH1A1MEN1LMNAPOLB | |
| SCHEMBL15240217 | 0.80 | B3GNT2 (0.45) | KDM4EALDH1A1B3GNT2S1PR3S1PR4 | |
| SCHEMBL29035228 | 0.79 | HDAC1 (0.37) | B3GNT2S1PR3S1PR4S1PR2S1PR1 | |
| SCHEMBL588788 | 0.78 | KDM4E (0.38) | KDM4EALDH1A1B3GNT2S1PR3S1PR4 | |
| SCHEMBL12541474 | 0.78 | SMN1; SMN2 (0.42) | KDM4EALDH1A1S1PR3S1PR1MEN1 | |
| SCHEMBL15380733 | 0.75 | MAPK1 (0.37) | ALDH1A1S1PR3S1PR4S1PR2MEN1 | |
| SCHEMBL67946 | 0.73 | IRAK4 (0.39) | ALDH1A1S1PR3S1PR4S1PR2MEN1 | |
| SCHEMBL12940584 | 0.73 | B3GNT2 (0.47) | KDM4EALDH1A1B3GNT2S1PR3S1PR4 | |
| SCHEMBL5741460 | 0.72 | SIRT2 (0.39) | KDM4EALDH1A1MEN1LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163928-B2 | Heteroaryl substituted benzothiazoles | ASTRAZENECA AB (SE) | 2012-04-24 | — | — | US | disclosed |