Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPRT1 | P00492 | 11/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | BLM | P54132 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | VCP | P55072 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | HBB | P68871 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | PNP | P00491 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | EDNRA | P25101 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20997452 | 0.87 | HPRT1 (0.58) | HPRT1CYP3A4BLMMEN1KMT2A | |
| SCHEMBL7262127 | 0.83 | CYP3A4 (0.62) | HPRT1CYP3A4PNP | |
| SCHEMBL15078235 | 0.82 | CYP3A4 (0.53) | HPRT1CYP3A4 | |
| SCHEMBL15078156 | 0.78 | POLB (0.55) | HPRT1CYP3A4PNP | |
| SCHEMBL15078154 | 0.78 | POLB (0.55) | HPRT1CYP3A4PNP | |
| SCHEMBL13991017 | 0.77 | KMT2A (0.50) | HPRT1CYP3A4BLMMEN1KMT2A | |
| SCHEMBL28511848 | 0.76 | HPRT1 (0.56) | HPRT1CYP3A4BLMMEN1KMT2A | |
| SCHEMBL20041166 | 0.75 | CYP3A4 (0.67) | CYP3A4ALDH1A1 | |
| SCHEMBL7745038 | 0.73 | HPRT1 (0.52) | HPRT1CYP3A4BLMMEN1KMT2A | |
| SCHEMBL20997370 | 0.72 | HPRT1 (0.70) | HPRT1CYP3A4BLMMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2794624-B1 | GUANINE ANALOGS AS TELOMERASE SUBSTRATES AND TELOMERE LENGTH AFFECTORS | GERON CORP (US) | 2019-05-15 | — | — | EP | disclosed |