Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aspartame. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY4R | P50391 | 7/20 | 0.57 |
| ▸ | NPY1R | P25929 | 5/20 | 0.57 |
| ▸ | NPY2R | P49146 | 4/20 | 0.47 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.45 |
| ▸ | ANPEP | P15144 | 1/20 | 0.44 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aspartame SCHEMBL2099793 | 1.00 | NPY4R (0.57) | NPY4RNPY1RNPY2RNPY5RHDAC3 | |
| SCHEMBL13445658 | 0.84 | NPY4R (0.58) | NPY4RNPY1RNPY2RNPY5R | |
| Arginine SCHEMBL16105142 | 0.82 | MMP2 (0.48) | NPY4RNPY1RNPY2RNPY5RANPEP | |
| Arginine SCHEMBL20503185 | 0.82 | MMP2 (0.48) | NPY4RNPY1RNPY2RNPY5RANPEP | |
| SCHEMBL30565144 | 0.82 | NPY4R (0.59) | NPY4RNPY1RNPY2RNPY5RMMP2 | |
| SCHEMBL30958098 | 0.82 | NPY4R (0.59) | NPY4RNPY1RNPY2RNPY5RMMP2 | |
| SCHEMBL30958097 | 0.82 | NPY4R (0.59) | NPY4RNPY1RNPY2RNPY5RMMP2 | |
| SCHEMBL30845381 | 0.82 | NPY4R (0.59) | NPY4RNPY1RNPY2RNPY5RMMP2 | |
| SCHEMBL29406322 | 0.82 | NPY4R (0.59) | NPY4RNPY1RNPY2RNPY5RMMP2 | |
| SCHEMBL29533534 | 0.81 | NPY4R (0.54) | NPY4RNPY1RNPY2RNPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9585708-B2 | Controlling coagulum formation | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2017-03-07 | — | — | US | disclosed |
| US-20160151105-A1 | CONTROLLING COAGULUM FORMATION | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH | 2016-06-02 | — | — | US | disclosed |
| US-9271786-B2 | Controlling coagulum formation | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2016-03-01 | — | — | US | disclosed |
| EP-2053981-B1 | COAGULUM FORMATION CONTROLLING APPARATUS | MAYO FOUNDATION (US) | 2015-11-18 | — | — | EP | disclosed |
| US-20140324040-A1 | Controlling Coagulum Formation | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH | 2014-10-30 | — | — | US | disclosed |
| US-8790338-B2 | Controlling coagulum formation | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2014-07-29 | — | — | US | disclosed |
| US-8409192-B2 | Controlling coagulum formation | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2013-04-02 | — | — | US | disclosed |
| US-20120150171-A1 | Controlling Coagulum Formation | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH | 2012-06-14 | — | — | US | disclosed |
| US-8162936-B2 | — | — | 2012-04-24 | — | — | US | disclosed |
| US-20090187187-A1 | Controlling Coagulum Formation | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2009-07-23 | — | — | US | disclosed |
| EP-2053981-A1 | COAGULUM FORMATION CONTROLLING APPARATUS | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008024714-A1 | COAGULUM FORMATION CONTROLLING APPARATUS | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2008-02-28 | — | — | WO | disclosed |