Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 18/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.57 |
| ▸ | JAK3 | P52333 | 4/20 | 0.51 |
| ▸ | LCK | P06239 | 2/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28106556 | 0.90 | BTK (0.59) | BTKKCNH2JAK3LCKEGFR | |
| SCHEMBL16671808 | 0.89 | BTK (0.78) | BTKKCNH2JAK3LCKEGFR | |
| SCHEMBL16676620 | 0.89 | BTK (0.78) | BTKKCNH2JAK3LCKEGFR | |
| SCHEMBL20998484 | 0.84 | BTK (0.79) | BTKKCNH2LCKEGFR | |
| SCHEMBL20998666 | 0.81 | BTK (0.79) | BTKKCNH2JAK3 | |
| SCHEMBL20998599 | 0.81 | BTK (0.54) | BTKKCNH2JAK3 | |
| SCHEMBL16676678 | 0.78 | BTK (0.80) | BTKKCNH2 | |
| SCHEMBL28106077 | 0.75 | BTK (0.66) | BTKKCNH2JAK3LCKEGFR | |
| SCHEMBL20998488 | 0.75 | BTK (0.82) | BTKKCNH2 | |
| SCHEMBL16676758 | 0.75 | BTK (0.82) | BTKKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3060550-B1 | HETEROARYL COMPOUNDS AS BTK INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2019-05-15 | — | — | EP | disclosed |