Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 20/20 | 0.79 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.59 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28106087 | 0.89 | BTK (0.78) | BTKKCNH2EGFRLCK | |
| SCHEMBL28106073 | 0.89 | BTK (0.78) | BTKKCNH2EGFRLCK | |
| SCHEMBL16671028 | 0.89 | BTK (1.00) | BTKKCNH2 | |
| SCHEMBL16676809 | 0.89 | BTK (1.00) | BTKKCNH2 | |
| SCHEMBL18044931 | 0.89 | BTK (1.00) | BTKKCNH2 | |
| SCHEMBL21100854 | 0.87 | BTK (0.78) | BTKKCNH2EGFRLCK | |
| SCHEMBL20998569 | 0.84 | BTK (0.61) | BTKKCNH2EGFRLCK | |
| SCHEMBL20998594 | 0.84 | BTK (0.80) | BTKKCNH2 | |
| SCHEMBL16671754 | 0.84 | BTK (1.00) | BTKKCNH2 | |
| SCHEMBL20998617 | 0.84 | BTK (1.00) | BTKKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3060550-B1 | HETEROARYL COMPOUNDS AS BTK INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2019-05-15 | — | — | EP | disclosed |