Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 18/20 | 0.57 |
| ▸ | JAK3 | P52333 | 3/20 | 0.48 |
| ▸ | LCK | P06239 | 3/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16676700 | 1.00 | BTK (0.57) | BTKJAK3LCKEGFR | |
| SCHEMBL18069917 | 0.87 | BTK (0.75) | BTKJAK3EGFR | |
| SCHEMBL20998681 | 0.87 | BTK (0.75) | BTKJAK3EGFR | |
| SCHEMBL18044988 | 0.86 | BTK (0.50) | BTKJAK3LCKEGFR | |
| SCHEMBL18044987 | 0.86 | BTK (0.50) | BTKJAK3LCKEGFR | |
| SCHEMBL18068376 | 0.85 | BTK (0.55) | BTKJAK3EGFR | |
| SCHEMBL16763797 | 0.81 | BTK (0.62) | BTKJAK3LCKEGFR | |
| SCHEMBL16763798 | 0.81 | BTK (0.62) | BTKJAK3LCKEGFR | |
| SCHEMBL16763638 | 0.78 | BTK (0.79) | BTKJAK3LCKEGFR | |
| SCHEMBL16763639 | 0.78 | BTK (0.79) | BTKJAK3LCKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3060550-B1 | HETEROARYL COMPOUNDS AS BTK INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2019-05-15 | — | — | EP | disclosed |