Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 14/20 | 0.45 |
| ▸ | SENP2 | Q9HC62 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.39 |
| ▸ | ALPI | P09923 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALPG | P10696 | 1/20 | 0.39 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20999058 | 0.93 | ATF4 (0.44) | ATF4SENP2POLBALPLALPI | |
| SCHEMBL20999638 | 0.88 | ATF4 (0.48) | ATF4POLB | |
| SCHEMBL22669375 | 0.87 | POLB (0.51) | ATF4SENP2POLBALPLALPI | |
| SCHEMBL20999681 | 0.86 | ATF4 (0.47) | ATF4SENP2POLBALPLALPI | |
| SCHEMBL20999049 | 0.85 | ATF4 (0.51) | ATF4 | |
| SCHEMBL20999613 | 0.85 | ATF4 (0.44) | ATF4SENP2POLBALPLALPI | |
| SCHEMBL20999204 | 0.85 | ATF4 (0.47) | ATF4SENP2POLB | |
| SCHEMBL30025462 | 0.85 | ATF4 (0.61) | ATF4 | |
| SCHEMBL19569600 | 0.85 | ATF4 (0.61) | ATF4 | |
| SCHEMBL20999226 | 0.84 | ATF4 (0.44) | ATF4SENP2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190144440-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ABBVIE INC. | 2019-05-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190144440-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ATF4, ATF1, DDIT3 | ATF4 1/4885SENP2 3515/4885POLB 1764/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.