Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.47 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.45 |
| ▸ | HSPB1 | P04792 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | S100A4 | P26447 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27897201 | 0.85 | TDP1 (0.47) | TDP1GPR35HSPB1ALDH1A1TSHR | |
| SCHEMBL27805782 | 0.83 | TDP1 (0.45) | TDP1GPR35HSPB1ALDH1A1TSHR | |
| SCHEMBL21685488 | 0.79 | TDP1 (0.45) | TDP1GPR35ALDH1A1TSHRMEN1 | |
| SCHEMBL8313252 | 0.78 | TDP1 (0.43) | TDP1GPR35HSPB1ALDH1A1TSHR | |
| SCHEMBL26119628 | 0.76 | KMT2A (0.42) | TDP1GPR35ALDH1A1TSHRMEN1 | |
| SCHEMBL29355089 | 0.75 | TDP1 (0.54) | TDP1GPR35HSPB1ALDH1A1TSHR | |
| SCHEMBL307855 | 0.75 | TDP1 (0.54) | TDP1GPR35HSPB1ALDH1A1TSHR | |
| SCHEMBL29482305 | 0.74 | TDP1 (0.56) | TDP1GPR35HSPB1ALDH1A1TSHR | |
| SCHEMBL5828 | 0.74 | TDP1 (0.56) | TDP1GPR35HSPB1ALDH1A1TSHR | |
| SCHEMBL12444133 | 0.74 | TDP1 (0.56) | TDP1GPR35HSPB1ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3713941-A1 | PYRAZOLOPYRIDINONE COMPOUNDS | Janssen Pharmaceutica NV (BE) | 2020-09-30 | — | — | EP | disclosed |
| WO-2019101182-A1 | PYRAZOLOPYRIDINONE COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2019-05-31 | — | — | WO | disclosed |