Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | S100A4 | P26447 | 2/20 | 0.39 |
| ▸ | PTPRC | P08575 | 1/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.37 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27897201 | 0.81 | TDP1 (0.47) | TDP1KMT2ATSHRMEN1SMN1; SMN2 | |
| SCHEMBL26119628 | 0.79 | KMT2A (0.42) | TDP1KMT2ATSHRMEN1SMN1; SMN2 | |
| SCHEMBL27010079 | 0.78 | TAAR1 (0.38) | TDP1KMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL21001071 | 0.78 | TDP1 (0.47) | TDP1KMT2ATSHRMEN1SMN1; SMN2 | |
| SCHEMBL27805782 | 0.76 | TDP1 (0.45) | TDP1KMT2ATSHRMEN1SMN1; SMN2 | |
| SCHEMBL27422713 | 0.73 | TDP1 (0.58) | TDP1KMT2ATSHRMEN1SMN1; SMN2 | |
| SCHEMBL2624225 | 0.73 | HSD17B10 (0.47) | TDP1KMT2ATSHRMEN1SMN1; SMN2 | |
| SCHEMBL14200052 | 0.73 | TDP1 (0.48) | TDP1KMT2ATSHRMEN1SMN1; SMN2 | |
| SCHEMBL8317898 | 0.70 | AOC3 (0.34) | TDP1TSHRSMN1; SMN2HSD17B10ALDH1A1 | |
| SCHEMBL20438397 | 0.70 | TDP1 (0.46) | TDP1KMT2ATSHRMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929072-A | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | ELI LILLY AND COMPANY LIMITED (GB) | 1999-07-27 | — | — | US | disclosed |
| WO-1999010346-A1 | BENZOTHIADIAZINYL-INDOLE DERIVATIVES AND THEIR USE AS SEROTONIN RECEPTOR LIGANDS | ELI LILLY AND COMPANY LIMITED (GB) | 1999-03-04 | — | — | WO | disclosed |
| EP-0897921-A1 | Benzothiadiazinyl-indole derivatives and their use as serotonin receptor ligands | ELI LILLY AND COMPANY LIMITED (GB) | 1999-02-24 | — | — | EP | disclosed |