SCHEMBL21008248

SCHEMBL21008248

c1ccc(-n2c3ccccc3c3ccc4sc5c(-n6c7ccccc7c7ccccc76)nccc5c4c32)cc1

nearest known ligand 0.41

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 1/20 0.41
▸ ATM Q13315 1/20 0.41
▸ L3MBTL1 Q9Y468 1/20 0.41
▸ HSD17B10 Q99714 1/20 0.32
▸ MCL1 Q07820 2/20 0.32
▸ PDE1B Q01064 1/20 0.32
▸ PDE3A Q14432 1/20 0.32
▸ PDE11A Q9HCR9 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21008249 0.93 KDM4E (0.34) KDM4EATML3MBTL1
SCHEMBL21007543 0.85 KDM4E (0.44) KDM4EATML3MBTL1HSD17B10PDE1B
SCHEMBL18593800 0.85 ATM (0.41) KDM4EATML3MBTL1HSD17B10MCL1
SCHEMBL21007301 0.84 KDM4E (0.40) KDM4EATML3MBTL1HSD17B10
SCHEMBL21008226 0.82 KDM4E (0.42) KDM4EATML3MBTL1HSD17B10MCL1
SCHEMBL21008240 0.82 GPR3 (0.34) KDM4EATML3MBTL1
SCHEMBL21007545 0.81 ATM (0.41) KDM4EATML3MBTL1HSD17B10MCL1
SCHEMBL21008106 0.81 KDM4E (0.37) KDM4EATML3MBTL1HSD17B10
SCHEMBL21007544 0.81 KDM4E (0.37) KDM4EATML3MBTL1HSD17B10
SCHEMBL21007522 0.81 KDM4E (0.37) KDM4EATML3MBTL1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11349081-B2 Azaindolocarbazole compounds Beijing Summer Sprout Technology Co., Ltd. (CN) 2022-05-31 — — US disclosed
US-20190148646-A1 AZAINDOLOCARBAZOLE COMPOUNDS Beijing Summer Sprout Technology Co., Ltd. (CN) 2019-05-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190148646-A1 AZAINDOLOCARBAZOLE COMPOUNDS SLC25A21, OXA1L, OCIAD1 KDM4E 1464/4885ATM 4426/4885L3MBTL1 3880/4885
US-11349081-B2 Azaindolocarbazole compounds SLC25A21, OXA1L, OCIAD1 KDM4E 1464/4885ATM 4426/4885L3MBTL1 3880/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback