Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KDM5C | P41229 | 1/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23471264 | 0.82 | HDAC3 (0.48) | NR1H4SMN1; SMN2NPC1LMNARAB9A | |
| SCHEMBL21015205 | 0.81 | HDAC6 (0.55) | NR1H4SMN1; SMN2NPC1LMNARAB9A | |
| SCHEMBL21015877 | 0.80 | ROCK2 (0.47) | NR1H4ROCK2SMN1; SMN2LMNAHDAC6 | |
| SCHEMBL21015944 | 0.80 | NR1H4 (0.45) | NR1H4ROCK2SMN1; SMN2NPC1LMNA | |
| SCHEMBL21015876 | 0.79 | NR1H4 (0.48) | NR1H4ROCK2SMN1; SMN2HDAC6PPARG | |
| SCHEMBL19634803 | 0.79 | TDP1 (0.50) | NR1H4ROCK2SMN1; SMN2LMNAHDAC6 | |
| SCHEMBL21015964 | 0.79 | NR1H4 (0.44) | NR1H4ROCK2SMN1; SMN2NPC1LMNA | |
| SCHEMBL21015487 | 0.77 | NR1H4 (0.43) | NR1H4ROCK2SMN1; SMN2NPC1LMNA | |
| SCHEMBL23471280 | 0.77 | NR1H4 (0.43) | NR1H4SMN1; SMN2NPC1LMNARAB9A | |
| SCHEMBL21015961 | 0.75 | NR1H4 (0.39) | NR1H4ROCK2SMN1; SMN2NPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190151403-A1 | NOVEL CYCLOSPORIN DERIVATIVES AND USES THEREOF | S&T GLOBAL INC. | 2019-05-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190151403-A1 | NOVEL CYCLOSPORIN DERIVATIVES AND USES THEREOF | MALT1, MYLK2, FKBP1B | NR1H4 1808/4885ROCK2 3054/4885SMN1; SMN2 781/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.