Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 7/20 | 0.64 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.61 |
| ▸ | PLG | P00747 | 3/20 | 0.53 |
| ▸ | PLAU | P00749 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.52 |
| ▸ | RELA | Q04206 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21018057 | 0.95 | ACHE (0.69) | ACHECHEK2PLGPLAUNPC1 | |
| SCHEMBL23153377 | 0.95 | ACHE (0.69) | ACHECHEK2PLGPLAUNPC1 | |
| SCHEMBL20982566 | 0.94 | ACHE (0.70) | ACHECHEK2PLGPLAUNPC1 | |
| SCHEMBL20982619 | 0.91 | CHEK2 (0.72) | ACHECHEK2PLGPLAUNPC1 | |
| SCHEMBL21017655 | 0.91 | ACHE (0.65) | ACHECHEK2NPC1ALDH1A1LMNA | |
| SCHEMBL21017614 | 0.90 | ACHE (0.65) | ACHECHEK2PLGPLAUALDH1A1 | |
| SCHEMBL21018380 | 0.89 | CHEK2 (0.71) | ACHECHEK2PLGPLAUNPC1 | |
| SCHEMBL21017802 | 0.89 | CHEK2 (0.62) | ACHECHEK2PLGPLAUNPC1 | |
| SCHEMBL23153375 | 0.89 | CHEK2 (0.62) | ACHECHEK2PLGPLAUNPC1 | |
| SCHEMBL21017228 | 0.88 | ACHE (0.66) | ACHECHEK2PLGPLAUALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190152924-A1 | BIS-BENZIMIDAZOLE COMPOUNDS AND METHODS OF USING THE SAME | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED | 2019-05-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190152924-A1 | BIS-BENZIMIDAZOLE COMPOUNDS AND METHODS OF USING THE SAME | HNRNPH1, HNRNPH3, HNRNPUL2 | ACHE 2382/4885CHEK2 1163/4885PLG 4082/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.