Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 4/20 | 0.70 |
| ▸ | ACHE | P22303 | 4/20 | 0.60 |
| ▸ | PPARG | P37231 | 1/20 | 0.57 |
| ▸ | PPARA | Q07869 | 1/20 | 0.57 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.54 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.54 |
| ▸ | P2RY12 | Q9H244 | 3/20 | 0.54 |
| ▸ | PDE2A | O00408 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20982542 | 0.92 | CHEK2 (0.61) | CHEK2ACHEPPARGPPARAPDE3B | |
| SCHEMBL20982619 | 0.90 | CHEK2 (0.72) | CHEK2ACHEKDM4ENPC1USP2 | |
| SCHEMBL21018380 | 0.89 | CHEK2 (0.71) | CHEK2ACHEKDM4ENPC1USP2 | |
| SCHEMBL20982527 | 0.88 | CHEK2 (0.78) | CHEK2ACHEHDAC6 | |
| SCHEMBL21018086 | 0.87 | CHEK2 (0.64) | CHEK2ACHEHDAC6HDAC3HDAC4 | |
| SCHEMBL21017590 | 0.87 | CHEK2 (0.69) | CHEK2ACHEPDE3BPDE3AP2RY12 | |
| SCHEMBL20982669 | 0.87 | CHEK2 (0.66) | CHEK2ACHEPPARGPPARAKDM4E | |
| SCHEMBL20982566 | 0.86 | ACHE (0.70) | CHEK2ACHEKDM4ENPC1USP2 | |
| SCHEMBL23153377 | 0.85 | ACHE (0.69) | CHEK2ACHEKDM4ENPC1USP2 | |
| SCHEMBL21017844 | 0.85 | CHEK2 (0.66) | CHEK2ACHEKDM4ENPC1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10961202-B2 | Bis-benzimidazole compounds and methods of using the same | THE SCRIPPS RESEARCH INSTITUTE (US) | 2021-03-30 | — | — | US | disclosed |
| US-20190152924-A1 | BIS-BENZIMIDAZOLE COMPOUNDS AND METHODS OF USING THE SAME | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED | 2019-05-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10961202-B2 | Bis-benzimidazole compounds and methods of using the same | HNRNPH1, HNRNPH3, HNRNPUL2 | CHEK2 1163/4885ACHE 2382/4885PPARG 4023/4885 |
| US-20190152924-A1 | BIS-BENZIMIDAZOLE COMPOUNDS AND METHODS OF USING THE SAME | HNRNPH1, HNRNPH3, HNRNPUL2 | CHEK2 1163/4885ACHE 2382/4885PPARG 4023/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.