SCHEMBL21020262

SCHEMBL21020262

CN(c1ccc([Si](C)(C)C)cc1)c1cccc2c1oc1ccccc12

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 3/20 0.35
MAPT P10636 2/20 0.35
TOP2A P11388 1/20 0.35
KMT2A Q03164 3/20 0.34
MEN1 O00255 2/20 0.34
CYP2C19 P33261 1/20 0.34
PGR P06401 1/20 0.34
TNKS O95271 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
KDM4E B2RXH2 2/20 0.33
ALDH1A1 P00352 2/20 0.33
HTT P42858 2/20 0.33
LMNA P02545 2/20 0.33
MAOA P21397 2/20 0.33
NPC1 O15118 1/20 0.33
RAB9A P51151 1/20 0.33
AHR P35869 1/20 0.33
POLB P06746 1/20 0.32
TSHR P16473 1/20 0.32
SMN1; SMN2 Q16637 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15747049 0.86 TOP2A (0.44) ALOX5MAPTTOP2AKMT2AMEN1
SCHEMBL17933247 0.85 C5AR1 (0.38) ALOX5MAPTTOP2AKMT2AMEN1
SCHEMBL20650243 0.84 ALOX5 (0.35) ALOX5MAPTKMT2AMEN1CYP2C19
SCHEMBL20800808 0.84 POLB (0.39) ALOX5MAPTTOP2AKMT2AMEN1
SCHEMBL19163849 0.84 ALOX5 (0.40) ALOX5MAPTTOP2AKMT2AMEN1
SCHEMBL21020265 0.83 CYP2C19 (0.40) ALOX5MAPTTOP2AKMT2AMEN1
SCHEMBL14295588 0.83 ALOX5 (0.38) ALOX5MAPTKMT2AMEN1CYP2C19
SCHEMBL21019982 0.83 MCL1 (0.34)
SCHEMBL21021030 0.83
SCHEMBL24206305 0.82 MEN1 (0.34) ALOX5MAPTKMT2AMEN1CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190152919-A1 COMPOUND AND ORGANIC ELECTRONIC ELEMENT COMPRISING SAME LG CHEM, LTD. (KR) 2019-05-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190152919-A1 COMPOUND AND ORGANIC ELECTRONIC ELEMENT COMPRISING SAME OR10J3, ETV6, ESR1 ALOX5 2172/4885MAPT 1486/4885TOP2A 1765/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.