SCHEMBL21020562

SCHEMBL21020562

Cc1ccc(-c2cc(NC(=O)C3C(c4ccc(C)c(Cl)c4)C3(Cl)Cl)ccc2C)cc1

nearest known ligand 0.49

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 6/20 0.49
MEN1 O00255 5/20 0.49
ALDH1A1 P00352 2/20 0.49
RECQL P46063 1/20 0.49
HTT P42858 3/20 0.48
LMNA P02545 3/20 0.46
HPGD P15428 1/20 0.46
MAPT P10636 3/20 0.43
MAPK1 P28482 1/20 0.43
MAPK14 Q16539 4/20 0.42
THRB P10828 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21021204 0.86 KMT2A (0.43) KMT2AMEN1ALDH1A1RECQLHTT
SCHEMBL21022118 0.83 KMT2A (0.50) KMT2AMEN1ALDH1A1RECQLHTT
SCHEMBL21021207 0.80 MEN1 (0.37) KMT2AMEN1ALDH1A1RECQLHTT
SCHEMBL21021817 0.78 MEN1 (0.53) KMT2AMEN1ALDH1A1RECQLHTT
SCHEMBL21021818 0.78 MEN1 (0.53) KMT2AMEN1ALDH1A1RECQLHTT
SCHEMBL21020626 0.77 MAPK14 (0.37) KMT2AMEN1ALDH1A1RECQLHTT
SCHEMBL20076747 0.76 MEN1 (0.48) KMT2AMEN1ALDH1A1RECQLHTT
SCHEMBL21021098 0.75 MEN1 (0.52) KMT2AMEN1ALDH1A1RECQLHTT
SCHEMBL21022044 0.75 MEN1 (0.52) KMT2AMEN1ALDH1A1RECQLHTT
SCHEMBL21022476 0.74 MEN1 (0.53) KMT2AMEN1ALDH1A1RECQLHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3283459-B1 MOLECULES HAVING PESTICIDAL UTILITY, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES, RELATED THERETO DOW AGROSCIENCES LLC (US) 2019-05-22 EP disclosed