Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | UBE2N | P61088 | 1/20 | 0.44 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | IDH1 | O75874 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30999699 | 0.85 | NPC1 (0.54) | NPC1RAB9AMAPTNPSR1HTT | |
| SCHEMBL12804825 | 0.83 | NPC1 (0.56) | NPC1RAB9AMAPTNPSR1HTT | |
| SCHEMBL31364581 | 0.83 | MAPT (0.54) | NPC1RAB9AMAPTNPSR1HTT | |
| SCHEMBL8259527 | 0.83 | NPC1 (0.58) | NPC1RAB9AMAPTNPSR1HTT | |
| SCHEMBL1354818 | 0.83 | NPC1 (0.52) | NPC1RAB9AMAPTNPSR1HTT | |
| SCHEMBL24484298 | 0.83 | NPC1 (0.52) | NPC1RAB9AMAPTNPSR1HTT | |
| SCHEMBL15299351 | 0.83 | NPC1 (0.52) | NPC1RAB9AMAPTNPSR1HTT | |
| SCHEMBL1094013 | 0.82 | NPC1 (0.63) | NPC1RAB9AMAPTNPSR1HTT | |
| SCHEMBL695186 | 0.79 | NPC1 (0.50) | NPC1RAB9AMAPTNPSR1HTT | |
| SCHEMBL4301398 | 0.79 | NPC1 (0.52) | NPC1RAB9AMAPTNPSR1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024103151-A1 | 1H-PYRAZOLE ANALOGUES AND METHODS AND USES THEREOF | UNIVERSITY OF MANITOBA (CA) | 2024-05-23 | — | — | WO | disclosed |
| EP-3080087-B1 | N-SUBSTITUTED PYRAZOLYL GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF | LYCERA CORP (US) | 2019-05-22 | — | — | EP | disclosed |
| CN-107739338-A | Formamide and urea derivative as capsaicin analog receptors ligand | 美迪福伦DBT有限公司 | 2018-02-27 | — | — | CN | disclosed |