Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.45 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.39 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.37 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16180356 | 0.81 | NPC1 (0.45) | NPC1MAPTRAB9AALDH1A1KDM4E | |
| SCHEMBL30518891 | 0.81 | NPC1 (0.45) | NPC1MAPTRAB9AALDH1A1KDM4E | |
| SCHEMBL30999699 | 0.79 | NPC1 (0.54) | NPC1MAPTRAB9AKDM4EMAPK1 | |
| SCHEMBL21023945 | 0.79 | NPC1 (0.54) | NPC1MAPTRAB9AKDM4EMAPK1 | |
| SCHEMBL16180341 | 0.78 | KCNJ1 (0.49) | NPC1MAPTRAB9AALDH1A1MAPK1 | |
| SCHEMBL24484298 | 0.77 | NPC1 (0.52) | NPC1MAPTRAB9AKDM4EMAPK1 | |
| SCHEMBL12804825 | 0.77 | NPC1 (0.56) | NPC1MAPTRAB9AKDM4EMAPK1 | |
| SCHEMBL8259527 | 0.77 | NPC1 (0.58) | NPC1MAPTRAB9AALDH1A1KDM4E | |
| SCHEMBL24409109 | 0.77 | ALDH1A1 (0.51) | ALDH1A1KDM4EMAPK1POLBNPSR1 | |
| SCHEMBL15299351 | 0.77 | NPC1 (0.52) | NPC1MAPTRAB9AKDM4EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8507533-B2 | Glucagon receptor modulators | PFIZER INC. (US) | 2013-08-13 | — | — | US | disclosed |
| US-8507533-B2 | Glucagon receptor modulators | PFIZER INC. (US) | 2013-08-13 | — | — | US | disclosed |
| US-20120202834-A1 | GLUCAGON RECEPTOR MODULATORS | PFIZER INC. (US) | 2012-08-09 | — | — | US | disclosed |
| US-20120202834-A1 | GLUCAGON RECEPTOR MODULATORS | PFIZER INC. (US) | 2012-08-09 | — | — | US | disclosed |
| US-20090270407-A1 | FUNGICIDAL ISOXAZOLIDINES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2009-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270407-A1 | FUNGICIDAL ISOXAZOLIDINES | XDH, CYP4X1, CYP1B1 | NPC1 655/4885MAPT 3942/4885RAB9A 428/4885 |
| US-20120202834-A1 | GLUCAGON RECEPTOR MODULATORS | GLP1R, GCGR, GPR119 | NPC1 1530/4885MAPT 4254/4885RAB9A 1825/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.