Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.42 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 3/20 | 0.41 |
| ▸ | EP300 | Q09472 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 6/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1257995 | 0.86 | NPSR1 (0.44) | NPSR1GLO1FAAHEP300ALDH1A1 | |
| SCHEMBL6067615 | 0.86 | NPSR1 (0.50) | NPSR1GLO1FAAHEP300ALDH1A1 | |
| SCHEMBL13269213 | 0.86 | NPSR1 (0.50) | NPSR1GLO1FAAHEP300ALDH1A1 | |
| SCHEMBL21024955 | 0.85 | NPSR1 (0.43) | NPSR1GLO1FAAHEP300ALDH1A1 | |
| SCHEMBL13269486 | 0.80 | EP300 (0.57) | NPSR1GLO1FAAHEP300ALDH1A1 | |
| SCHEMBL6067678 | 0.80 | EP300 (0.57) | NPSR1GLO1FAAHEP300ALDH1A1 | |
| SCHEMBL21024953 | 0.80 | EP300 (0.49) | NPSR1GLO1FAAHEP300ALDH1A1 | |
| SCHEMBL8995719 | 0.80 | EP300 (0.53) | NPSR1GLO1FAAHEP300ALDH1A1 | |
| SCHEMBL8995695 | 0.80 | EP300 (0.53) | NPSR1GLO1FAAHEP300ALDH1A1 | |
| SCHEMBL4351912 | 0.79 | FAAH (0.45) | NPSR1GLO1FAAHEP300ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3119772-B1 | HETEROARYL SIK INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2019-05-22 | — | — | EP | disclosed |