⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21673477 | 0.80 | — | — | |
| SCHEMBL20155648 | 0.75 | — | — | |
| SCHEMBL1702353 | 0.72 | HMGCR (0.30) | — | |
| SCHEMBL24026540 | 0.70 | SMN1; SMN2 (0.39) | — | |
| SCHEMBL20696793 | 0.69 | ALOX5AP (0.31) | — | |
| SCHEMBL18068056 | 0.69 | CYP3A4 (0.34) | — | |
| SCHEMBL25996323 | 0.69 | — | — | |
| SCHEMBL12197725 | 0.66 | CYP3A4 (0.43) | — | |
| SCHEMBL5950443 | 0.66 | NOS3 (0.33) | — | |
| SCHEMBL15457960 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11065231-B2 | Compounds and methods for the targeted degradation of interleukin-1 receptor- associated kinase 4 polypeptides | ARVINAS OPERATIONS, INC. (US) | 2021-07-20 | — | — | US | disclosed |
| US-20190300521-A1 | BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE | GENENTECH, INC. | 2019-10-03 | — | — | US | disclosed |
| US-20190151295-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 4 POLYPEPTIDES | ARVINAS OPERATIONS, INC. | 2019-05-23 | — | — | US | disclosed |