Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.43 |
| ▸ | SRC | P12931 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21026153 | 0.94 | SIGMAR1 (0.51) | SIGMAR1NPSR1ALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL21025782 | 0.90 | SIGMAR1 (0.48) | SIGMAR1NPSR1ALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL21025785 | 0.84 | SIGMAR1 (0.51) | SIGMAR1NPSR1ALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL17678347 | 0.83 | KDM4E (0.51) | HDAC1HDAC2ALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL21026152 | 0.82 | KDM4E (0.50) | SIGMAR1HDAC1ALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL23479575 | 0.81 | TDP1 (0.49) | NPSR1ALDH1A1HSD17B10SMN1; SMN2L3MBTL1 | |
| SCHEMBL521597 | 0.80 | HSD17B10 (0.64) | HDAC1HDAC2ALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL2950344 | 0.80 | MAPK1 (0.49) | HDAC1HDAC2ALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL15828632 | 0.79 | NPC1 (0.49) | HDAC1ALDH1A1HSD17B10SMN1; SMN2KDM4E | |
| SCHEMBL21025783 | 0.79 | KDM4E (0.48) | SIGMAR1HDAC1ALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190151312-A1 | HEPARAN SULFATE BIOSYNTHESIS INHIBITORS FOR THE TREATMENT OF DISEASES | BIOMARIN PHARMACEUTICAL INC. | 2019-05-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190151312-A1 | HEPARAN SULFATE BIOSYNTHESIS INHIBITORS FOR THE TREATMENT OF DISEASES | HPSE, GAA, MAN2B1 | SIGMAR1 3139/4885HDAC1 217/4885HDAC2 647/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.