Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 8/20 | 0.52 |
| ▸ | CDK9 | P50750 | 8/20 | 0.52 |
| ▸ | CDK7 | P50613 | 8/20 | 0.52 |
| ▸ | CCNH | P51946 | 6/20 | 0.52 |
| ▸ | MNAT1 | P51948 | 5/20 | 0.52 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.49 |
| ▸ | CDK2 | P24941 | 5/20 | 0.49 |
| ▸ | CCNK | O75909 | 5/20 | 0.42 |
| ▸ | CDK12 | Q9NYV4 | 5/20 | 0.42 |
| ▸ | HTR6 | P50406 | 5/20 | 0.42 |
| ▸ | EGFR | P00533 | 5/20 | 0.42 |
| ▸ | DRD2 | P14416 | 3/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | HTR7 | P34969 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19024518 | 0.92 | CDK7 (0.51) | CCNT1CDK9CDK7CCNHMNAT1 | |
| SCHEMBL20536159 | 0.92 | CDK7 (0.51) | CCNT1CDK9CDK7CCNHMNAT1 | |
| SCHEMBL17688395 | 0.92 | CDK7 (0.51) | CCNT1CDK9CDK7CCNHMNAT1 | |
| SCHEMBL17150473 | 0.92 | CDK7 (0.51) | CCNT1CDK9CDK7CCNHMNAT1 | |
| SCHEMBL17150411 | 0.90 | CDK7 (0.51) | CCNT1CDK9CDK7CCNHMNAT1 | |
| SCHEMBL16665199 | 0.88 | CDK7 (0.58) | CCNT1CDK9CDK7CCNHMNAT1 | |
| SCHEMBL20994616 | 0.86 | CDK7 (0.46) | CCNT1CDK9CDK7CCNHMNAT1 | |
| SCHEMBL19024485 | 0.86 | CDK7 (0.46) | CCNT1CDK9CDK7CCNHMNAT1 | |
| SCHEMBL19024551 | 0.86 | CDK7 (0.46) | CCNT1CDK9CDK7CCNHMNAT1 | |
| SCHEMBL16655188 | 0.86 | CDK7 (0.46) | CCNT1CDK9CDK7CCNHMNAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3489232-A2 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | Syros Pharmaceuticals, Inc. (US) | 2019-05-29 | — | — | EP | disclosed |