Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 5/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.46 |
| ▸ | CDK9 | P50750 | 5/20 | 0.46 |
| ▸ | CCNH | P51946 | 4/20 | 0.46 |
| ▸ | MNAT1 | P51948 | 4/20 | 0.46 |
| ▸ | CDK2 | P24941 | 9/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.43 |
| ▸ | HTR6 | P50406 | 2/20 | 0.40 |
| ▸ | JUN | P05412 | 7/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 7/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 7/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 6/20 | 0.40 |
| ▸ | EGFR | P00533 | 5/20 | 0.40 |
| ▸ | CCNK | O75909 | 2/20 | 0.39 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16655188 | 1.00 | CDK7 (0.46) | CDK7CCNT1CDK9CCNHMNAT1 | |
| SCHEMBL19024551 | 1.00 | CDK7 (0.46) | CDK7CCNT1CDK9CCNHMNAT1 | |
| SCHEMBL19024485 | 1.00 | CDK7 (0.46) | CDK7CCNT1CDK9CCNHMNAT1 | |
| SCHEMBL19024458 | 0.91 | HTR6 (0.39) | CDK7CCNT1CDK9CCNHMNAT1 | |
| SCHEMBL21027469 | 0.86 | CCNT1 (0.52) | CDK7CCNT1CDK9CCNHMNAT1 | |
| SCHEMBL20536159 | 0.85 | CDK7 (0.51) | CDK7CCNT1CDK9CCNHMNAT1 | |
| SCHEMBL19024518 | 0.85 | CDK7 (0.51) | CDK7CCNT1CDK9CCNHMNAT1 | |
| SCHEMBL17150473 | 0.85 | CDK7 (0.51) | CDK7CCNT1CDK9CCNHMNAT1 | |
| SCHEMBL17688395 | 0.85 | CDK7 (0.51) | CDK7CCNT1CDK9CCNHMNAT1 | |
| SCHEMBL20549548 | 0.84 | CDK7 (0.46) | CDK7CCNT1CDK9CCNHMNAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3489232-A2 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | Syros Pharmaceuticals, Inc. (US) | 2019-05-29 | — | — | EP | disclosed |