Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | IGF1R | P08069 | 11/20 | 0.46 |
| ▸ | CDK2 | P24941 | 7/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | JUN | P05412 | 1/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 9/20 | 0.45 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.44 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.44 |
| ▸ | CDK7 | P50613 | 3/20 | 0.43 |
| ▸ | CDK9 | P50750 | 3/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3314551 | 0.85 | FLT3 (0.48) | PKMIGF1RCDK2FLT3JUN | |
| SCHEMBL27474684 | 0.83 | PKM (0.51) | PKMIGF1RCDK2FLT3MAP3K14 | |
| SCHEMBL21027484 | 0.80 | IGF1R (0.56) | IGF1RCDK2JUNMAPK8MAPK9 | |
| SCHEMBL1613993 | 0.78 | MAP3K14 (0.60) | IGF1RCDK2FLT3EPHB3MAP3K14 | |
| SCHEMBL22252929 | 0.74 | CDK2 (0.64) | IGF1RCDK2FLT3JUNMAPK8 | |
| SCHEMBL22228839 | 0.74 | CDK2 (0.64) | IGF1RCDK2FLT3JUNMAPK8 | |
| SCHEMBL31500953 | 0.74 | CDK2 (0.64) | IGF1RCDK2FLT3JUNMAPK8 | |
| SCHEMBL4804170 | 0.74 | DYRK1A (0.66) | PKMIGF1RCDK2FLT3MAPK8 | |
| SCHEMBL20812676 | 0.72 | IGF1R (0.68) | IGF1RCDK2KCNH2 | |
| SCHEMBL3313332 | 0.71 | FLT3 (0.46) | PKMIGF1RCDK2FLT3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3489232-A2 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | Syros Pharmaceuticals, Inc. (US) | 2019-05-29 | — | — | EP | disclosed |