Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 6/20 | 0.59 |
| ▸ | PIK3CD | O00329 | 17/20 | 0.59 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.45 |
| ▸ | PRKDC | P78527 | 1/20 | 0.45 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.41 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9884081 | 0.91 | PIK3CG (0.69) | PIK3CGPIK3CDPIK3CBPIK3CAABL1 | |
| SCHEMBL18708650 | 0.86 | PIK3CD (0.71) | PIK3CGPIK3CDPIK3CBPIK3CAABL1 | |
| SCHEMBL9884097 | 0.85 | PIK3CG (0.78) | PIK3CGPIK3CDPIK3CBPIK3CAABL1 | |
| SCHEMBL18879425 | 0.83 | PIK3CG (0.68) | PIK3CGPIK3CDPIK3CBPIK3CAABL1 | |
| SCHEMBL9884341 | 0.83 | PIK3CD (0.67) | PIK3CGPIK3CDPIK3CBPIK3CAABL1 | |
| SCHEMBL28392472 | 0.82 | PIK3CG (0.69) | PIK3CGPIK3CDPIK3CBPIK3CAABL1 | |
| SCHEMBL21028944 | 0.82 | PIK3CG (0.63) | PIK3CGPIK3CDPIK3CBPIK3CAABL1 | |
| SCHEMBL9884080 | 0.81 | PIK3CD (0.68) | PIK3CGPIK3CDPIK3CBPIK3CAABL1 | |
| SCHEMBL958791 | 0.81 | PIK3CD (0.68) | PIK3CGPIK3CDPIK3CBPIK3CAABL1 | |
| SCHEMBL29479398 | 0.81 | PIK3CD (0.68) | PIK3CGPIK3CDPIK3CBPIK3CAABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2240452-B1 | 1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE DERIVATIVES AS PI3 KINASE MODULATORS, THEIR COMPOSITIONS AND USES | INTELLIKINE LLC (US) | 2019-05-29 | — | — | EP | disclosed |