Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 3/20 | 0.73 |
| ▸ | NPC1 | O15118 | 13/20 | 0.59 |
| ▸ | RAB9A | P51151 | 13/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.59 |
| ▸ | TP53 | P04637 | 3/20 | 0.59 |
| ▸ | ACP1 | P24666 | 1/20 | 0.59 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 5/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.56 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.56 |
| ▸ | RELA | Q04206 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18612696 | 0.86 | DYRK1A (0.67) | DYRK1ANPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL14189678 | 0.84 | DYRK1A (0.73) | DYRK1ANPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL2175580 | 0.84 | DYRK1A (1.00) | DYRK1ANPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL12683251 | 0.83 | DYRK1A (0.74) | DYRK1ANPC1RAB9ATP53ALDH1A1 | |
| SCHEMBL13486495 | 0.80 | DYRK1A (0.76) | DYRK1ANPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL22467930 | 0.80 | DYRK1A (0.67) | DYRK1ANPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL15993384 | 0.80 | DYRK1A (0.67) | DYRK1ANPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL21568049 | 0.80 | DYRK1A (0.76) | DYRK1ANPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL10936133 | 0.80 | DYRK1A (0.74) | DYRK1ANPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL14113317 | 0.79 | DYRK1A (0.74) | DYRK1ANPC1RAB9ASMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2240452-B1 | 1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE DERIVATIVES AS PI3 KINASE MODULATORS, THEIR COMPOSITIONS AND USES | INTELLIKINE LLC (US) | 2019-05-29 | — | — | EP | disclosed |