Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB2 | P30411 | 13/20 | 0.43 |
| ▸ | RORC | P51449 | 7/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22334224 | 0.95 | BDKRB2 (0.44) | BDKRB2RORCCYP3A4CYP2C19 | |
| SCHEMBL24426997 | 0.93 | BDKRB2 (0.44) | BDKRB2RORCCYP3A4CYP2C19 | |
| SCHEMBL21030783 | 0.90 | BDKRB2 (0.42) | BDKRB2RORCCYP3A4CYP2C19 | |
| SCHEMBL22334189 | 0.90 | BDKRB2 (0.42) | BDKRB2RORCCYP3A4CYP2C19 | |
| SCHEMBL24427006 | 0.89 | BDKRB2 (0.40) | BDKRB2RORC | |
| SCHEMBL24426996 | 0.89 | BDKRB2 (0.40) | BDKRB2RORC | |
| SCHEMBL24427000 | 0.89 | BDKRB2 (0.40) | BDKRB2RORC | |
| SCHEMBL24427007 | 0.89 | BDKRB2 (0.40) | BDKRB2RORC | |
| SCHEMBL24426930 | 0.89 | BDKRB2 (0.41) | BDKRB2RORCCYP3A4CYP2C19 | |
| SCHEMBL21030171 | 0.89 | BDKRB2 (0.41) | BDKRB2RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3998259-A1 | NOVEL BRADYKININ B2 RECEPTOR ANTAGONISTS | Pharvaris Netherlands B.V. (NL) | 2022-05-18 | — | — | EP | disclosed |
| EP-3713928-B1 | NOVEL BRADYKININ B2 RECEPTOR ANTAGONISTS | PHARVARIS NETHERLANDS B V (NL) | 2022-01-12 | — | — | EP | disclosed |
| WO-2019101906-A1 | NOVEL BRADYKININ B2 RECEPTOR ANTAGONISTS | PHARVARIS B.V. (NL) | 2019-05-31 | — | — | WO | disclosed |