Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 3/20 | 0.45 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.42 |
| ▸ | CMA1 | P23946 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.40 |
| ▸ | GRIA1 | P42261 | 5/20 | 0.38 |
| ▸ | CACNG8 | Q8WXS5 | 5/20 | 0.38 |
| ▸ | TDP2 | O95551 | 5/20 | 0.36 |
| ▸ | CACNG2 | Q9Y698 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | IDH1 | O75874 | 1/20 | 0.32 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18210189 | 0.83 | AHR (0.38) | AHRMALT1CMA1GABRA1GABRB1 | |
| SCHEMBL5357730 | 0.77 | GRIA1 (0.49) | AHRMALT1CMA1GRIA1CACNG8 | |
| SCHEMBL25066324 | 0.77 | AHR (0.56) | AHRCMA1GRIA1CACNG8TDP2 | |
| SCHEMBL4410702 | 0.74 | AHR (0.49) | AHRMALT1CMA1GRIA1CACNG8 | |
| SCHEMBL25899903 | 0.74 | AHR (0.49) | AHRMALT1CMA1GRIA1CACNG8 | |
| SCHEMBL17292981 | 0.74 | AHR (0.49) | AHRMALT1CMA1GRIA1CACNG8 | |
| SCHEMBL17591353 | 0.73 | AHR (0.45) | AHRMALT1CMA1GRIA1CACNG8 | |
| SCHEMBL2611032 | 0.72 | AHR (0.56) | AHRGABRA1GABRB1GRIA1CACNG8 | |
| SCHEMBL18238548 | 0.71 | BMPR1A (0.39) | AHRMALT1GRIA1CACNG8TDP2 | |
| SCHEMBL19710584 | 0.70 | AHR (0.49) | AHRCMA1GRIA1CACNG8PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210052556-A1 | SUBSTITUTED THIAZOLO-PYRIDINE COMPOUNDS AS MALT1 INHIBITORS | LUPIN LTD (IN) | 2021-02-25 | — | — | US | disclosed |
| US-20190275012-A9 | SUBSTITUTED THIAZOLO-PYRIDINE COMPOUNDS AS MALT1 INHIBITORS | LUPIN LIMITED (IN) | 2019-09-12 | — | — | US | disclosed |
| US-20190160045-A1 | SUBSTITUTED THIAZOLO-PYRIDINE COMPOUNDS AS MALT1 INHIBITORS | LUPIN LTD (IN) | 2019-05-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210052556-A1 | SUBSTITUTED THIAZOLO-PYRIDINE COMPOUNDS AS MALT1 INHIBITORS | MALT1, PTP4A1, PTPRO | AHR 3628/4885MALT1 1/4885CMA1 27/4885 |
| US-20190275012-A9 | SUBSTITUTED THIAZOLO-PYRIDINE COMPOUNDS AS MALT1 INHIBITORS | MALT1, PTP4A1, PTPRO | AHR 3628/4885MALT1 1/4885CMA1 27/4885 |
| US-20190160045-A1 | SUBSTITUTED THIAZOLO-PYRIDINE COMPOUNDS AS MALT1 INHIBITORS | MALT1, PTP4A1, PTPRO | AHR 3628/4885MALT1 1/4885CMA1 27/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.