SCHEMBL21030552

SCHEMBL21030552

Cc1cc(Cl)c(COc2cccc3c(-n4cc(F)cn4)cc(C)nc23)c([C@H](C)NC(=O)c2ccncc2)c1

nearest known ligand 0.48

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ BDKRB2 P30411 20/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22334265 0.95 BDKRB2 (0.48) BDKRB2
SCHEMBL21030567 0.93 BDKRB2 (0.47) BDKRB2
SCHEMBL21030565 0.91 BDKRB2 (0.46) BDKRB2
SCHEMBL24427029 0.89 BDKRB2 (0.45) BDKRB2
SCHEMBL24427033 0.89 BDKRB2 (0.45) BDKRB2
SCHEMBL24426844 0.89 BDKRB2 (0.46) BDKRB2
SCHEMBL22334168 0.89 BDKRB2 (0.47) BDKRB2
SCHEMBL24426909 0.88 BDKRB2 (0.46) BDKRB2
SCHEMBL24426908 0.88 BDKRB2 (0.46) BDKRB2
SCHEMBL24426835 0.88 BDKRB2 (0.43) BDKRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3998259-A1 NOVEL BRADYKININ B2 RECEPTOR ANTAGONISTS Pharvaris Netherlands B.V. (NL) 2022-05-18 — — EP disclosed
EP-3713928-B1 NOVEL BRADYKININ B2 RECEPTOR ANTAGONISTS PHARVARIS NETHERLANDS B V (NL) 2022-01-12 — — EP disclosed
WO-2019101906-A1 NOVEL BRADYKININ B2 RECEPTOR ANTAGONISTS PHARVARIS B.V. (NL) 2019-05-31 — — WO disclosed
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