Sugi Predict

Sugi Predict / Compounds / SCHEMBL21030795

SCHEMBL21030795

SCHEMBL21030795

Cc1cc(-n2ccnn2)c2cccc(OCc3c(Cl)cc(F)cc3[C@H](C)NC(=O)[C@H]3CCOC3)c2n1

nearest known ligand 0.43

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ BDKRB2 P30411 17/20 0.43
▸ RORC P51449 3/20 0.39
▸ CYP3A4 P08684 1/20 0.35
▸ CYP2C19 P33261 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24426860 0.94 BDKRB2 (0.44) BDKRB2RORCCYP3A4CYP2C19
SCHEMBL21030790 0.90 BDKRB2 (0.40) BDKRB2RORCCYP3A4CYP2C19
SCHEMBL22662459 0.90 BDKRB2 (0.40) BDKRB2RORCCYP3A4CYP2C19
SCHEMBL21030783 0.89 BDKRB2 (0.42) BDKRB2RORCCYP3A4CYP2C19
SCHEMBL22334189 0.89 BDKRB2 (0.42) BDKRB2RORCCYP3A4CYP2C19
SCHEMBL22334250 0.84 BDKRB2 (0.45) BDKRB2RORCCYP3A4
SCHEMBL22334240 0.84 BDKRB2 (0.45) BDKRB2RORCCYP3A4
SCHEMBL22334245 0.84 BDKRB2 (0.45) BDKRB2RORCCYP3A4
SCHEMBL22334224 0.84 BDKRB2 (0.44) BDKRB2RORCCYP3A4CYP2C19
SCHEMBL21030330 0.80 BDKRB2 (0.43) BDKRB2RORC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11820756-B2 Bradykinin B2 receptor antagonists Pharvaris Netherlands B.V. (NL) 2023-11-21 — — US disclosed
US-11820756-B2 Bradykinin B2 receptor antagonists Pharvaris Netherlands B.V. (NL) 2023-11-21 — — US disclosed
US-20220135543-A1 NOVEL BRADYKININ B2 RECEPTOR ANTAGONISTS Pharvaris Netherlands B.V. (NL) 2022-05-05 — — US disclosed
EP-3713928-B1 NOVEL BRADYKININ B2 RECEPTOR ANTAGONISTS PHARVARIS NETHERLANDS B V (NL) 2022-01-12 — — EP disclosed
US-20210017158-A1 NOVEL BRADYKININ B2 RECEPTOR ANTAGONISTS ANALYTICON DISCOVERY GMBH (DE) 2021-01-21 — — US disclosed
US-10836748-B2 Bradykinin B2 receptor antagonists Pharvaris Netherlands B.V. (NL) 2020-11-17 — — US disclosed
US-20200255405-A1 NOVEL BRADYKININ B2 RECEPTOR ANTAGONISTS ANALYTICON DISCOVERY GMBH (DE) 2020-08-13 — — US disclosed
WO-2019101906-A1 NOVEL BRADYKININ B2 RECEPTOR ANTAGONISTS PHARVARIS B.V. (NL) 2019-05-31 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210017158-A1 NOVEL BRADYKININ B2 RECEPTOR ANTAGONISTS BDKRB2, BDKRB1, VIPR2 BDKRB2 1/4885RORC 4082/4885CYP3A4 2143/4885
US-20220135543-A1 NOVEL BRADYKININ B2 RECEPTOR ANTAGONISTS BDKRB2, BDKRB1, VIPR2 BDKRB2 1/4885RORC 4082/4885CYP3A4 2143/4885
US-10836748-B2 Bradykinin B2 receptor antagonists BDKRB2, BDKRB1, VIPR2 BDKRB2 1/4885RORC 4230/4885CYP3A4 1840/4885
US-11820756-B2 Bradykinin B2 receptor antagonists BDKRB2, BDKRB1, VIPR2 BDKRB2 1/4885RORC 4230/4885CYP3A4 1840/4885
US-20200255405-A1 NOVEL BRADYKININ B2 RECEPTOR ANTAGONISTS BDKRB2, BDKRB1, VIPR2 BDKRB2 1/4885RORC 4082/4885CYP3A4 2143/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.