⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19523377 | 0.89 | TDP1 (0.36) | — | |
| SCHEMBL504033 | 0.89 | — | — | |
| SCHEMBL5412906 | 0.75 | TDP1 (0.36) | — | |
| SCHEMBL7643702 | 0.75 | FAAH (0.31) | — | |
| SCHEMBL3298704 | 0.74 | — | — | |
| SCHEMBL1938092 | 0.74 | — | — | |
| SCHEMBL11109724 | 0.74 | TDP1 (0.33) | — | |
| SCHEMBL11351354 | 0.74 | — | — | |
| SCHEMBL45517 | 0.73 | — | — | |
| SCHEMBL16710684 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 114 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957198-A1 | CARBONYLATION OF ETHYLENICALLY UNSATURATED COMPOUNDS | Lucite International UK Limited (GB) | 2008-08-20 | — | — | EP | claimed |
| WO-2007057640-A1 | CARBONYLATION OF ETHYLENICALLY UNSATURATED COMPOUNDS | LUCITE INTERNATIONAL UK LIMITED (GB) | 2007-05-24 | — | — | WO | claimed |
| EP-3737673-B1 | PROCESS FOR PREPARING HALICHONDRIN MACROLIDES AND ANALOGS THEREOF BY A PRINS REACTION, AND INTERMEDIATES OF THIS PROCESS | EISAI R&D MAN CO LTD (JP) | 2024-03-06 | — | — | EP | disclosed |
| CN-117024469-A | Macrocyclization reactions useful for the synthesis of halichondrin macrolides, intermediates and other fragments | 卫材R&D管理有限公司 | 2023-11-10 | — | — | CN | disclosed |
| CN-112250692-B | Macrocyclization reactions useful for the synthesis of halichondrin macrolides, intermediates and other fragments | 卫材R&D管理有限公司 | 2023-08-29 | — | — | CN | disclosed |
| US-11713329-B2 | Intermediates useful in the preparation of halichondrin compounds and methods for preparing the same | BEIJING TIENYI LUFU PHARMATECH CO. LTD. (CN) | 2023-08-01 | — | — | US | disclosed |
| EP-3763696-B1 | PRODUCTION METHOD FOR GAMMA, DELTA-UNSATURATED ALCOHOLS | KURARAY CO (JP) | 2023-07-05 | — | — | EP | disclosed |
| US-20230151022-A1 | PRINS REACTION AND COMPOUNDS USEFUL IN THE SYNTHESIS OF HALICHONDRIN MACROLIDES AND ANALOGS THEREOF | EISAI R&D MANAGEMENT CO, LTD. (JP) | 2023-05-18 | — | — | US | disclosed |
| US-11643418-B2 | Macrocyclization reactions and intermediates and other fragments useful in the synthesis of analogs of halichondrin B | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2023-05-09 | — | — | US | disclosed |
| US-11542269-B2 | Prins reaction and compounds useful in the synthesis of halichondrin macrolides and analogs thereof | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2023-01-03 | — | — | US | disclosed |
| CN-114805322-A | Prins reactions and intermediates useful for the synthesis of halichondrin macrolides and analogs thereof | 卫材R&D管理有限公司 | 2022-07-29 | — | — | CN | disclosed |
| US-5053551-A | PROCESS FOR THE PRODUCTION OF ALDEHYDES BY HYDROFORMYLATION | DAVY MCKEE (LONDON) LIMITED (GB) | 1991-10-01 | — | — | US | disclosed |
| EP-0313559-B1 | PROCESS FOR THE PRODUCTION OF ALDEHYDES BY HYDROFORMYLATION | DAVY McKEE (LONDON) LIMITED (GB) | 1991-08-28 | — | — | EP | disclosed |
| EP-0313559-A1 | PROCESS FOR THE PRODUCTION OF ALDEHYDES BY HYDROFORMYLATION. | DAVY MCKEE LONDON (GB) | 1989-05-03 | — | — | EP | disclosed |
| US-4792636-A | DEGASSING LIQUID HYDROFORMYLATION PRODUCT MEDIUM WHICH CONTAINS RHODIUM COMPLEX HYDROFORMYLATION CATALYST | DAVY MCKEE (LONDON) LIMITED (GB) | 1988-12-20 | — | — | US | disclosed |
| EP-0037671-B1 | SHAPE SELECTIVE ACID CATALYZED REACTIONS OF OLEFINS OVER CRYSTALLINE ZEOLITES | MOBIL OIL CORPORATION (US) | 1983-03-30 | — | — | EP | disclosed |
| US-4324940-A | PREFERENTIAL REACTION OF SMALLER AND LINEAR OLEFINS | MOBIL OIL CORPORATION (US) | 1982-04-13 | — | — | US | disclosed |
| US-4322355-A | Production of 1,3-difunctional compounds | NATIONAL DISTILLERS & CHEMICAL CORP. (US) | 1982-03-30 | — | — | US | disclosed |
| EP-0037671-A1 | Shape selective acid catalyzed reactions of olefins over crystalline zeolites | MOBIL OIL CORPORATION (US) | 1981-10-14 | — | — | EP | disclosed |
| US-4028424-A | FROM AN ALPHA-OLEFIN AND AN ALDEHYDE | JAPAN SYNTHETIC RUBBER CO., LTD. (JA) | 1977-06-07 | — | — | US | disclosed |