Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | FER | P16591 | 5/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1986224 | 0.79 | FER (0.46) | KMT2ANFKB1EGFRERBB2MAPT | |
| SCHEMBL22475481 | 0.77 | FER (0.43) | KMT2ANFKB1EGFRMAPTGAA | |
| SCHEMBL30041532 | 0.71 | EGFR (0.57) | KMT2ANFKB1EGFRERBB2KDM4E | |
| SCHEMBL26101728 | 0.71 | EGFR (0.57) | KMT2ANFKB1EGFRERBB2KDM4E | |
| SCHEMBL28257227 | 0.69 | KMT2A (0.53) | KMT2ANFKB1EGFRKDM4EMAPT | |
| SCHEMBL12755667 | 0.67 | NFKB1 (0.55) | KMT2ANFKB1EGFRKDM4EMAPT | |
| SCHEMBL30041610 | 0.65 | EGFR (0.50) | KMT2AEGFRERBB2KDM4ELMNA | |
| SCHEMBL1986212 | 0.65 | EGFR (0.44) | KMT2AEGFRERBB2MAPTMEN1 | |
| SCHEMBL19790518 | 0.65 | AURKA (0.49) | KMT2AKDM4EMAPTGAAFER | |
| SCHEMBL10254010 | 0.65 | NFKB1 (0.49) | NFKB1MAPTFERLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3489236-A1 | PROCESS FOR THE PREPARATION OF FUSED HETEROAROMATIC PYRROLIDINONES | Takeda Pharmaceutical Company Limited (JP) | 2019-05-29 | — | — | EP | disclosed |