Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 9/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.55 |
| ▸ | MAPK3 | P27361 | 3/20 | 0.55 |
| ▸ | FER | P16591 | 11/20 | 0.50 |
| ▸ | JAK2 | O60674 | 2/20 | 0.46 |
| ▸ | LCK | P06239 | 2/20 | 0.46 |
| ▸ | JAK3 | P52333 | 2/20 | 0.46 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.46 |
| ▸ | CDC7 | O00311 | 1/20 | 0.46 |
| ▸ | PLK4 | O00444 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.46 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26288005 | 1.00 | SYK (0.55) | SYKKCNH2AURKBMAPK1MAPK3 | |
| SCHEMBL1989061 | 1.00 | SYK (0.55) | SYKKCNH2AURKBMAPK1MAPK3 | |
| SCHEMBL1988137 | 0.94 | SYK (0.55) | SYKKCNH2AURKBMAPK1MAPK3 | |
| SCHEMBL1990154 | 0.93 | SYK (0.53) | SYKKCNH2AURKBMAPK1MAPK3 | |
| SCHEMBL21032636 | 0.93 | SYK (0.53) | SYKKCNH2AURKBMAPK1MAPK3 | |
| SCHEMBL12564466 | 0.93 | SYK (0.53) | SYKKCNH2AURKBMAPK1MAPK3 | |
| SCHEMBL1990157 | 0.93 | SYK (0.53) | SYKKCNH2AURKBMAPK1MAPK3 | |
| SCHEMBL1990152 | 0.93 | SYK (0.53) | SYKKCNH2AURKBMAPK1MAPK3 | |
| SCHEMBL16751306 | 0.82 | FER (0.54) | SYKKCNH2AURKBMAPK1MAPK3 | |
| SCHEMBL1985436 | 0.81 | SYK (0.56) | SYKKCNH2AURKBMAPK1MAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3825316-A1 | FUSED HETEROAROMATIC PYRROLIDINONES AS SYK INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2021-05-26 | — | — | EP | disclosed |
| EP-3489236-B1 | PROCESS FOR THE PREPARATION OF FUSED HETEROAROMATIC PYRROLIDINONES | TAKEDA PHARMACEUTICALS CO (JP) | 2020-09-30 | — | — | EP | disclosed |
| EP-3489236-A1 | PROCESS FOR THE PREPARATION OF FUSED HETEROAROMATIC PYRROLIDINONES | Takeda Pharmaceutical Company Limited (JP) | 2019-05-29 | — | — | EP | disclosed |