Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 8/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 4/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 5/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18867172 | 0.84 | MAPT (0.41) | IKBKBMAPTGAAALDH1A1LMNA | |
| SCHEMBL22986624 | 0.83 | IKBKB (0.42) | IKBKBMAPTGAAALDH1A1LMNA | |
| SCHEMBL18838775 | 0.83 | IKBKB (0.40) | IKBKBMAPTGAAALDH1A1LMNA | |
| SCHEMBL18838764 | 0.83 | IKBKB (0.40) | IKBKBMAPTGAAALDH1A1LMNA | |
| SCHEMBL20515380 | 0.83 | IKBKB (0.40) | IKBKBMAPTGAAALDH1A1LMNA | |
| SCHEMBL22986638 | 0.80 | IKBKB (0.38) | IKBKBMAPTGAAALDH1A1LMNA | |
| SCHEMBL21035280 | 0.76 | MAPT (0.37) | IKBKBMAPTGAAALDH1A1LMNA | |
| SCHEMBL18838772 | 0.75 | IKBKB (0.47) | IKBKBMAPTGAAALDH1A1LMNA | |
| SCHEMBL18838768 | 0.74 | CYP2D6 (0.40) | IKBKBMAPTGAAALDH1A1LMNA | |
| SCHEMBL31031239 | 0.73 | CYP2D6 (0.44) | IKBKBMAPTGAAALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10301308-B2 | Azetidine derivatives for tau imaging | ELI LILLY AND COMPANY (US) | 2019-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10301308-B2 | Azetidine derivatives for tau imaging | MAPT, PSEN2, PSEN1 | IKBKB 1915/4885MAPT 1/4885GAA 184/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.