Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18838764 | 1.00 | IKBKB (0.40) | IKBKBMAPTALDH1A1GAALMNA | |
| SCHEMBL31031217 | 0.90 | HTR3E (0.40) | ALDH1A1GAALMNATP53POLB | |
| SCHEMBL31031221 | 0.90 | HTR3E (0.40) | ALDH1A1GAALMNATP53POLB | |
| SCHEMBL18867172 | 0.88 | MAPT (0.41) | IKBKBMAPTALDH1A1GAALMNA | |
| SCHEMBL22986624 | 0.87 | IKBKB (0.42) | IKBKBMAPTALDH1A1GAALMNA | |
| SCHEMBL18838775 | 0.87 | IKBKB (0.40) | IKBKBMAPTALDH1A1GAALMNA | |
| SCHEMBL22986638 | 0.86 | IKBKB (0.38) | IKBKBMAPTALDH1A1GAALMNA | |
| SCHEMBL21035441 | 0.83 | IKBKB (0.42) | IKBKBMAPTALDH1A1GAALMNA | |
| SCHEMBL21035280 | 0.80 | MAPT (0.37) | IKBKBMAPTALDH1A1GAALMNA | |
| SCHEMBL31031246 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3374358-B1 | AZETIDINE DERIVATIVES FOR TAU IMAGING | LILLY CO ELI (US) | 2021-02-17 | — | — | EP | disclosed |
| US-10301308-B2 | Azetidine derivatives for tau imaging | ELI LILLY AND COMPANY (US) | 2019-05-28 | — | — | US | disclosed |
| US-20180282322-A1 | AZETIDINE DERIVATIVES FOR TAU IMAGING | ELI LILLY AND COMPANY | 2018-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10301308-B2 | Azetidine derivatives for tau imaging | MAPT, PSEN2, PSEN1 | IKBKB 1915/4885MAPT 1/4885ALDH1A1 4225/4885 |
| US-20180282322-A1 | AZETIDINE DERIVATIVES FOR TAU IMAGING | MAPT, PSEN2, PSEN1 | IKBKB 1915/4885MAPT 1/4885ALDH1A1 4225/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.