Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 2/20 | 0.53 |
| ▸ | AKT2 | P31751 | 2/20 | 0.53 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.53 |
| ▸ | MC4R | P32245 | 3/20 | 0.50 |
| ▸ | KDM1A | O60341 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | STS | P08842 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21036752 | 1.00 | AKT1 (0.53) | AKT1AKT2AKT3MC4RKDM1A | |
| SCHEMBL16825770 | 0.87 | KDM1A (0.48) | MC4RKDM1AMAPTALDH1A1KEAP1 | |
| SCHEMBL28630580 | 0.85 | AKT1 (0.45) | AKT1AKT2AKT3MC4RKDM1A | |
| SCHEMBL21124434 | 0.85 | AKT1 (0.45) | AKT1AKT2AKT3MC4RKDM1A | |
| SCHEMBL6345217 | 0.83 | HDAC8 (0.56) | AKT1AKT2AKT3HDAC8STS | |
| SCHEMBL19576823 | 0.80 | AKT1 (0.58) | AKT1AKT2AKT3MC4RHDAC8 | |
| SCHEMBL14507098 | 0.80 | SLC6A4 (0.55) | KDM1AMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL17276773 | 0.79 | ALDH1A1 (0.72) | KDM1AMAPTALDH1A1POLBMEN1 | |
| SCHEMBL4402074 | 0.79 | KDM1A (0.46) | KDM1AMAPTALDH1A1KEAP1NFE2L2 | |
| SCHEMBL19664137 | 0.79 | NPC1 (0.42) | AKT1AKT2AKT3HDAC8HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3489231-B1 | PIPERAZINE DERIVATIVE | ASTELLAS PHARMA INC (JP) | 2021-06-09 | — | — | EP | disclosed |
| EP-3489231-A1 | PIPERAZINE DERIVATIVE | Astellas Pharma Inc. (JP) | 2019-05-29 | — | — | EP | disclosed |