SCHEMBL21036855

SCHEMBL21036855

CN(CCOC(=O)NCc1ccc(COc2nc(N)nc3[nH]cnc23)cc1)c1ccc2nc(/C=C(\C#N)c3nc4ccccc4s3)sc2c1

nearest known ligand 0.38

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
MAPT P10636 7/20 0.36
MEN1 O00255 4/20 0.36
KMT2A Q03164 4/20 0.36
ALDH1A1 P00352 1/20 0.36
HTT P42858 1/20 0.34
POLB P06746 2/20 0.32
LMNA P02545 2/20 0.32
RAB9A P51151 1/20 0.32
KDM4E B2RXH2 1/20 0.32
RECQL P46063 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21037396 0.92 MAPT (0.43) MAPTMEN1KMT2AALDH1A1HTT
SCHEMBL21037014 0.92 MAPT (0.35) MAPTMEN1KMT2AALDH1A1HTT
SCHEMBL24089619 0.91 MAPT (0.35) MAPTMEN1KMT2AALDH1A1HTT
SCHEMBL21036854 0.91 MAPT (0.33) MAPTMEN1KMT2ARAB9AKDM4E
SCHEMBL21037068 0.90 MAPT (0.34) MAPTMEN1KMT2AALDH1A1HTT
SCHEMBL21036982 0.88 APP (0.34)
SCHEMBL24089749 0.88 MAPT (0.33) MAPTMEN1KMT2AALDH1A1HTT
SCHEMBL21036837 0.87 MAPT (0.34) MAPTMEN1KMT2AALDH1A1HTT
SCHEMBL21036820 0.87 MAPT (0.36) MAPTMEN1KMT2AALDH1A1HTT
SCHEMBL21036992 0.86 PIN1 (0.33)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11209437-B2 Fluorescent probe and preparation method and use thereof FLUORESCENCE DIAGNOSIS (SHANGHAI) BIOTECH COMPANY (CN) 2021-12-28 US disclosed
US-20190187144-A1 FLUORESCENT PROBE AND PREPARATION METHOD AND USE THEREOF EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) 2019-06-20 US disclosed
EP-3489324-A1 FLUORESCENT PROBE AND PREPARATION METHOD AND USE THEREOF East China University of Science and Technology (CN) 2019-05-29 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190187144-A1 FLUORESCENT PROBE AND PREPARATION METHOD AND USE THEREOF HNRNPF, HNRNPUL2, RAB5IF MAPT 2624/4885MEN1 2099/4885KMT2A 4751/4885
US-11209437-B2 Fluorescent probe and preparation method and use thereof HNRNPF, HNRNPUL2, RAB5IF MAPT 2624/4885MEN1 2099/4885KMT2A 4751/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.