Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VHL | P40337 | 1/20 | 0.51 |
| ▸ | ELOC | Q15369 | 1/20 | 0.51 |
| ▸ | ELOB | Q15370 | 1/20 | 0.51 |
| ▸ | VEGFA | P15692 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | RYR2 | Q92736 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29595944 | 0.78 | VHL (0.64) | VHLELOCELOBKDM4EHTT | |
| SCHEMBL12743 | 0.78 | VHL (0.64) | VHLELOCELOBKDM4EHTT | |
| SCHEMBL29596397 | 0.77 | KDM4E (0.77) | VHLELOCELOBKDM4EHTT | |
| SCHEMBL11283 | 0.77 | KDM4E (0.77) | VHLELOCELOBKDM4EHTT | |
| SCHEMBL6086566 | 0.73 | VHL (0.50) | VHLELOCELOBKDM4EHTT | |
| SCHEMBL16825565 | 0.71 | VEGFA (0.43) | VEGFA | |
| SCHEMBL13339009 | 0.70 | VHL (0.50) | VHLELOCELOBKDM4EHTT | |
| SCHEMBL5118761 | 0.69 | VHL (0.51) | VHLELOCELOBKDM4EHTT | |
| SCHEMBL7222447 | 0.69 | KDM4E (0.63) | VHLELOCELOBKDM4EHTT | |
| SCHEMBL10050688 | 0.69 | KDM4E (0.48) | VHLELOCELOBKDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3083639-B1 | CYCLIC SULFONE AND SULFOXIMINE ANALOGS AND USES THEREOF | PELOTON THERAPEUTICS INC (US) | 2019-05-29 | — | — | EP | disclosed |